You certainly won't hurt anything.
My personal view (and just my view) is -
If you pre-mix gas/oil in the tank then plain old "dino-oil" is fine. It mixes well and stays mixed well in the tank.
I use semi-synthetic in my OMC's that have Variable Rate Oilers (VRO's) - why? because it's a little (thinner) than dino-oil and I just figure it mixes a little better since the oil is introduced right at the fuel pump.
If I had an injected engine I would run synthetic (which is thinner again then semi) and just figure it would "squeeze through the injectors better".
If I had a direct injected motor I absolutely would use DFI rated synthetic oil since there is no mixing of the gas/oil until it's right in the cylinder.
But that's just me..