"If you have a complete carb t
"If you have a complete carb to pan and coupler to w/p 5.0 CHEVROLET (not Ford) Mercruiser engine of similar or exact year to the 4.3, then it's not hard. Just need to make sure your engine compartment has room. And then you may need different gears in your outdrive depending on the HP of the 2 engines (There were some 4.3's in more recent times that actually made more HP than some 5.0's).
If going V8, why not go 5.7...hardley seems worth it to swap for more weight and marginal HP increases.
A lot of missing info from your question tho' - like the year of the 5.0- important...and whether it's complete with manifolds etc"