Thanks for all your help on this.
The end result is that one of two stuck bolts came out after lots of patient work: propane heat, PB Blaster, tap-taps, more penetrating fluid with ATF and acetone mixed 1:1, slowly turning taking "no more that it gives you", but one broke off flush with the frame anyway. So, now I don't believe there is any possibility to drill it out, because the boat is on a lift and I have to work on a float. Since the zinc is located on the bottom of the frame, that would mean working on a floating platform trying to drill it upside down! I have no tow vehicle or a catamaran trailer.
One possible solution is to replace the bar zinc that was originally attached with two bolts with a different type zinc attached to the one good hole. However, this solution might result in inadequate zinc protection; I don't know how much it actually takes to do the job. Any thoughts on this or other suggestions? Thanks, Stan