Those little "Nail-head" Buick V6's are a cute motor in any small street rod, as not many people use them and therefore are a good talking point. Nostalgia - yes, but better engines in later years Too heavy, and virtually no speed equipment for them.
But, I wouldn't hesitate using one if I had no access to any others. The 225 in my own boat is performing beautifully, when I use it, that is.
But, back to the original question, wasn't the last Buick to use this motor in a car, back in 1966? But, Jeep then used them for many years.
My OMC Stern Drive has a multiple bolt pattern so if you can't get a V6, there are engines from Chev, etc that will fit. Even a Cadillac I think will fit one of the patterns. But, this would break the drive.
If you end up not using the stern drive unit, then I just might be interested, if it is the same as mine.
Bruce.